The Pleiotropic Gene Theory of Senescence: Supportive Evidence from Human Genetic Disease
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چکیده
Senescence is a universal but poorly understood phenomenon among metaxoans. One theoretically convincing but unproven evolutionary theory of senescence is the pleiotropic gene theory of Williams (1957). This paper develops the hypothesis that some human genetic diseases exemplify the type of phenotypic effects predicted by this theory. The evidence supporting this contention is reviewed and ways of testing this hypothesis are suggested. Other human genetic diseases could be examined in the same manner. Confirmation of this theory would have significant implications for the study of aging.
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تاریخ انتشار 2002